{"id":560,"date":"2018-10-27T08:00:02","date_gmt":"2018-10-26T23:00:02","guid":{"rendered":"https:\/\/www.sj-shibuya-bc.jp\/staff-blog\/?p=560"},"modified":"2020-12-26T15:23:48","modified_gmt":"2020-12-26T06:23:48","slug":"%e5%a6%8a%e5%a8%a0%e3%81%ab%e9%87%8d%e8%a6%81%e3%81%aa%e6%a0%84%e9%a4%8a%e7%b4%a0%e3%80%8e%e3%83%93%e3%82%bf%e3%83%9f%e3%83%b3d%e3%80%8f%e3%81%a8%e3%80%8e%e3%82%ab%e3%83%ab%e3%82%b7%e3%82%a6-2","status":"publish","type":"post","link":"https:\/\/www.sj-shibuya-bc.jp\/staff-blog\/?p=560","title":{"rendered":"\u598a\u5a20\u306b\u91cd\u8981\u306a\u6804\u990a\u7d20 \u30d3\u30bf\u30df\u30f3D\u3068\u30ab\u30eb\u30b7\u30a6\u30e0"},"content":{"rendered":"

\u685c\u5341\u5b57\u30a6\u30a3\u30e1\u30f3\u30ba\u30af\u30ea\u30cb\u30c3\u30af\u6e0b\u8c37\u57f9\u990a\u90e8\u3067\u3059\u3002<\/p>\n

\u904e\u53bb\u306b\u3001\u300c\u9b5a\u4ecb\u985e\u3092\u591a\u304f\u6442\u53d6\u3059\u308b\u30ab\u30c3\u30d7\u30eb\u306f\u598a\u5a20\u3057\u3084\u3059\u304f\u306a\u308b<\/a>\u300d\u3068\u3044\u3046\u7814\u7a76\u767a\u8868\u3092\u3054\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\u9b5a\u4ecb\u985e\u306b\u306f\u30d3\u30bf\u30df\u30f3D\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u591a\u304f\u542b\u307e\u308c\u3001\u3053\u306e\uff12\u3064\u306e\u6804\u990a\u7d20\u304c\u201c\u598a\u5a20\u306e\u524d\u5f8c\u306b\u7a4d\u6975\u7684\u306b\u6442\u308a\u305f\u3044\u6804\u990a\u7d20\u201d\u3068\u3057\u3066\u8449\u9178\u3068\u540c\u69d8\u306b\u6ce8\u76ee\u3092\u6d74\u3073\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306f\u3001\u4e16\u754c\u30c8\u30c3\u30d7\u30ec\u30d9\u30eb\u306e\u5185\u5206\u6ccc\u81e8\u5e8a\u7814\u7a76\u306b\u95a2\u3059\u308b\u67fb\u8aad\u8a8cThe Journal of Clinical Endocrinology and Metabolism<\/em>\u304b\u3089\u3001\u3053\u308c\u3089\u306e\u6804\u990a\u7d20\u306b\u95a2\u3059\u308b\u6700\u65b0\u306e\u7814\u7a76\u3092\u3054\u7d39\u4ecb\u3057\u305f\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u30d3\u30bf\u30df\u30f3D\u3084\u30ab\u30eb\u30b7\u30a6\u30e0\u306f\u5973\u6027\u306e\u8eab\u4f53\u306f\u3082\u3061\u308d\u3093\u3001\u80ce\u5150\u306e\u9aa8\u3084\u6b6f\u306e\u767a\u9054\u306b\u975e\u5e38\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3046\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30d3\u30bf\u30df\u30f3D\u306f\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u4f53\u5185\u3078\u306e\u53d6\u308a\u8fbc\u307f\u3092\u4fc3\u9032\u3059\u308b\u50cd\u304d\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5b9f\u306f\u201c\u30d3\u30bf\u30df\u30f3\u201d\u3068\u540d\u524d\u304c\u4ed8\u3044\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u5973\u6027\u30db\u30eb\u30e2\u30f3\u3084\u7537\u6027\u30db\u30eb\u30e2\u30f3\u306a\u3069\u306e\u3044\u308f\u3086\u308b\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u306b\u975e\u5e38\u306b\u4f3c\u305f\u69cb\u9020\u304c\u3042\u308a\u3001\u30db\u30eb\u30e2\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u598a\u5a20\u306e\u524d\u5f8c\u306b\u3082\u5927\u304d\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u3059\u3002<\/p>\n

\u30d3\u30bf\u30df\u30f3D\u304c\u598a\u5a20\u306b\u53ca\u307c\u3059\u5f71\u97ff<\/h4>\n

\u30d3\u30bf\u30df\u30f3D\u306f\u592a\u967d\u306e\u5149\u306b\u5f53\u305f\u308b\u3053\u3068\uff08\u65e5\u5149\u66dd\u9732\uff09\u306b\u3088\u3063\u3066\u4f53\u5185\u3067\u3082\u5408\u6210\u3055\u308c\u3001\u4e0d\u8db3\u3059\u308b\u3068\u4ed6\u306e\u52d5\u7269\u7a2e\u3067\u306f\u7e41\u6b96\u529b\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3093\u306a\u30d3\u30bf\u30df\u30f3D\u3067\u3059\u304c\u3001\u30a4\u30bf\u30ea\u30a2\u30fb\u30df\u30e9\u30ce\u306b\u3042\u308bOspedale Maggiore\u75c5\u9662\u3068\u30df\u30e9\u30ce\u5927\u5b66\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u3092\u793a\u3057\u305f\u5973\u6027\u306f\u5341\u5206\u306a\u30ec\u30d9\u30eb\u306e\u30d3\u30bf\u30df\u30f3D\u3092\u6709\u3059\u308b\u5973\u6027\u3068\u6bd4\u8f03\u3057\u3066\u3001\u4f53\u5916\u53d7\u7cbe\uff08IVF\uff09\u3067\u306e\u751f\u5150\u7372\u5f97\u7387\u304c\u534a\u6e1b\u3059\u308b\u3068\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u7814\u7a76\u3092\u7387\u3044\u305fAlessio Paffoni\u533b\u5e2b\u306f\u300c\u672c\u7814\u7a76\u306f\u30d3\u30bf\u30df\u30f3D\u304cIVF\u3092\u53d7\u3051\u3066\u3044\u308b\u5973\u6027\u306e\u598a\u5a20\u306b\u304a\u3044\u3066\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u306e\u304b\u3092\u8abf\u3079\u305f\u904e\u53bb\u6700\u5927\u306e\u7814\u7a76\u3067\u3042\u308b\u300d\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n

Paffoni\u533b\u5e2b\u3089\u306e\u30c1\u30fc\u30e0\u306f2012\u5e74\u306e\u4e00\u5e74\u9593\u306bOspedale Maggiore\u75c5\u9662 \u751f\u6b96\u533b\u7642\u30e6\u30cb\u30c3\u30c8\u306b\u304a\u3044\u3066IVF\u3092\u53d7\u3051\u305f335\u4eba\u306e\u60a3\u8005\u3092\u62bd\u51fa\u3057\u3001\u30d3\u30bf\u30df\u30f3D\u304c\u5341\u5206\u306a\u30ec\u30d9\u30eb\u306b\u3042\u308b\u30b0\u30eb\u30fc\u30d7\uff08181\u4eba\uff09\u3068\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u3092\u793a\u3057\u305f\u30b0\u30eb\u30fc\u30d7\uff08154\u4eba\uff09\u306b\u9078\u5225\u3057\u3066\u3001\u3053\u306e\u4e21\u30b0\u30eb\u30fc\u30d7\u3092\u5bfe\u8c61\u3068\u3057\u3066\u81e8\u5e8a\u598a\u5a20\u7387\u306e\u6bd4\u8f03\u691c\u8a0e\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u5bfe\u8c61\u3068\u306a\u3063\u305f\u60a3\u8005\u306f18\u6b73\u304b\u308942\u6b73\u307e\u3067\u306e\u5973\u6027\u3067\u4e21\u30b0\u30eb\u30fc\u30d7\u306e\u9593\u306b\u5e73\u5747\u5e74\u9f62\u3084BMI\u5024\u306a\u3069\u306b\u5dee\u306f\u7121\u304f\u3001\u60aa\u6027\u75be\u60a3\u3001\u9ad8\u8840\u5727\u3001\u7cd6\u5c3f\u75c5\u3001\u591a\u767a\u6027\u786c\u5316\u75c7\u306a\u3069\u306e\u65e2\u5f80\u304c\u3042\u308b\u60a3\u8005\u306f\u9664\u5916\u3055\u308c\u305f\u305f\u3081\u3001\u904e\u53bb\u306e\u75c5\u6b74\u306a\u3069\u306b\u3082\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u306a\u304a\u3001\u4e00\u822c\u7684\u306b\u5065\u5eb7\u7684\u306a\u72b6\u614b\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u308b\u8840\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u91cf\u306f30 ng \/ ml\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u672c\u7814\u7a76\u3067\u306f\u5c11\u306a\u304f\u3068\u308220 ng \/ ml\u4ee5\u4e0a\u3092\u793a\u3057\u305f\u5973\u6027\u306f\u5341\u5206\u306a\u30ec\u30d9\u30eb\u306b\u3042\u308b\u3068\u307f\u306a\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u598a\u5a20\u7387\u306e\u6bd4\u8f03\u7d50\u679c<\/h5>\n

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Paffoni\u533b\u5e2b\u306f\u30d3\u30bf\u30df\u30f3D\u304c\u5341\u5206\u306a\u30ec\u30d9\u30eb\u3092\u793a\u3059\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u6027\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u3082\u5b89\u5b9a\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u308b\u305f\u3081\u3001\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u3092\u793a\u3059\u30b0\u30eb\u30fc\u30d7\u3088\u308a\u3082\u826f\u8cea\u306a\u5375\u5b50\u3092\u7372\u5f97\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u9855\u8457\u306b\u9ad8\u304f\u3001\u7d50\u679c\u7684\u306b\u81e8\u5e8a\u598a\u5a20\u7387\u304c\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u7406\u8ad6\u4ed8\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n

Paffoni\u533b\u5e2b\u306f\u300c\u672c\u7814\u7a76\u306f\u30d3\u30bf\u30df\u30f3D\u306e\u6b20\u4e4f\u304c\u4e0d\u598a\u75c7\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u300d\u3068\u3057\u300c\u30d3\u30bf\u30df\u30f3D\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3084\u91ce\u5916\u3067\u6d3b\u52d5\u3059\u308b\u3053\u3068\u306f\u3001\u5b89\u4fa1\u3067\u7c21\u5358\u306b\u9032\u3081\u3089\u308c\u308b\u6cbb\u7642\u65b9\u6cd5\u306e\u7b2c\u4e00\u6b69\u306b\u306a\u308a\u5f97\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u300d\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30d3\u30bf\u30df\u30f3D\u306e\u5fc5\u8981\u6442\u53d6\u91cf<\/h4>\n

\u7d9a\u3044\u3066\u3001\u81e8\u5e8a\u6804\u990a\u5b66\u306e\u30ab\u30c6\u30b4\u30ea\u3067\u6700\u3082\u9ad8\u3044\u8a55\u4fa1\u3092\u53d7\u3051\u3066\u3044\u308b\u5b66\u8853\u8a8cThe American Journal of Clinical Nutrition<\/em> \u3088\u308a\u3001\u30d3\u30bf\u30df\u30f3D\u306a\u3089\u3073\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u306b\u95a2\u3059\u308b\u6700\u65b0\u306e\u7814\u7a76\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n

\u30ab\u30ca\u30c0\u30fb\u30d0\u30f3\u30af\u30fc\u30d0\u30fc\u306eChild\uff06Family Research Institute\uff08CFRI\uff09\u306e\u4e0a\u7d1a\u79d1\u5b66\u8005\u3067\u3001British Columbia University\u3067\u98df\u54c1\u30b7\u30b9\u30c6\u30e0\u5b66\u3092\u52d9\u3081\u308bTim J. Green\u51c6\u6559\u6388\u306f\u3001\u598a\u5a20\u306e\u524d\u5f8c\u306b\u30d3\u30bf\u30df\u30f3D\u3092\u542b\u3080\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6442\u53d6\u3057\u3066\u3044\u305f\u5973\u6027\u304c\u3001\u98df\u4e8b\u3084\u65e5\u5149\u66dd\u9732\u304b\u3089\u306f\u5341\u5206\u306a\u91cf\u304c\u6442\u53d6\u3067\u304d\u3066\u3044\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u672c\u8ad6\u6587\u3067\u306f\u30ab\u30ca\u30c0\u56fd\u5185\u306e\u598a\u5a20\u4e2d\u306e\u5973\u6027336\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u3092\u542b\u3080\u3044\u304f\u3064\u304b\u306e\u30d3\u30bf\u30df\u30f3\u306e\u8840\u4e2d\u6fc3\u5ea6\u3092\u6e2c\u5b9a\u3057\u3001\u30ab\u30ca\u30c0\u4fdd\u5065\u7701\u306a\u3089\u3073\u306b\u5b66\u4f1a\u304c\u63a8\u5968\u3057\u3066\u3044\u308b\u30ec\u30d9\u30eb\u3068\u306e\u6bd4\u8f03\u691c\u8a0e\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u7d0465\uff05\u306e\u5973\u6027\u306b\u304a\u3044\u3066\u30ab\u30ca\u30c0\u7523\u79d1\u5b66\u4f1a\u304c\u63a8\u5968\u3057\u3066\u3044\u308b\u598a\u5a20\u4e2d\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u3088\u308a\u3082\u4f4e\u3044\u5024\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u7d0424\uff05\u306e\u5973\u6027\u3067\u306f\u30ab\u30ca\u30c0\u4fdd\u5065\u7701\u304c\u63a8\u5968\u3059\u308b\u4e00\u822c\u306e\u6210\u4eba\u5973\u6027\uff08\u598a\u5a20\u3057\u3066\u3044\u306a\u3044\u5973\u6027\uff09\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u30ec\u30d9\u30eb\u3088\u308a\u3082\u4f4e\u3044\u5024\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n

Green\u6559\u6388\u306f\u300c\u30d3\u30bf\u30df\u30f3D\u306a\u3089\u3073\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u3001\u5973\u6027\u306e\u598a\u5a20\u306e\u30d7\u30ed\u30bb\u30b9\u3084\u598a\u5a20\u5f8c\u306e\u80ce\u5150\u306e\u767a\u80b2\u30fb\u5065\u5eb7\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3053\u3068\u306f\u5206\u304b\u3063\u3066\u3044\u308b\u304c\u3001\u73fe\u6bb5\u968e\u3067\u306f\u598a\u5a20\u524d\u5f8c\u306b\u304a\u3044\u3066\u5973\u6027\u304c\u6700\u9069\u306a\u5065\u5eb7\u72b6\u614b\u3092\u5f97\u308b\u305f\u3081\u306b\u3001\u30d3\u30bf\u30df\u30f3D\u304c\u3069\u308c\u3060\u3051\u5fc5\u8981\u304b\u306b\u3064\u3044\u3066\u306f\u4e16\u754c\u4e2d\u306e\u7814\u7a76\u8005\u304c\u6a21\u7d22\u3057\u3066\u3044\u308b\u6bb5\u968e\u3067\u3042\u308b\u300d\u3068\u3059\u308b\u4e00\u65b9\u3067\u300c\u56fd\u3084\u5b66\u4f1a\u304b\u3089\u591a\u304f\u306e\u52e7\u544a\u304c\u3042\u308b\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u304b\u306a\u308a\u306e\u6570\u306e\u5973\u6027\u304c\u5341\u5206\u306a\u30ec\u30d9\u30eb\u306e\u6804\u990a\u7d20\u3092\u5f97\u3066\u3044\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3092\u3053\u306e\u7814\u7a76\u306f\u660e\u3089\u304b\u306b\u3057\u305f\u300d\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u308c\u307e\u3067\u306b\u3082\u304a\u4f1d\u3048\u3057\u305f\u901a\u308a\u3001\u30d3\u30bf\u30df\u30f3D\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u306f\u9aa8\u3084\u6b6f\u306e\u6210\u9577\u30fb\u767a\u80b2\u306b\u4e0d\u53ef\u6b20\u306a\u6804\u990a\u7d20\u3067\u3059\u3002\u80ce\u5150\u306b\u304a\u3044\u3066\u306f\u30d3\u30bf\u30df\u30f3D\u306e\u6b20\u4e4f\u304c\u51fa\u751f\u4f53\u91cd\u306e\u6e1b\u5c11\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3084\u3001\u304f\u308b\u75c5\uff08\u4e73\u5e7c\u5150\u306e\u9aa8\u683c\u7570\u5e38\u3092\u793a\u3059\u75c5\u6c17\uff09\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u5148\u884c\u7814\u7a76\u3088\u308a\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u3092\u793a\u3059\u65b0\u751f\u5150\u3067\u306f\u5c06\u6765\u7684\u306b\u9aa8\u7c97\u9b06\u75c7\u30841\u578b\u7cd6\u5c3f\u75c5\u3001\u5598\u606f\u306a\u3069\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u672c\u8ad6\u6587\u3067\u306f\u30d3\u30bf\u30df\u30f3D\u304c\u4e0d\u8db3\u3057\u304c\u3061\u306b\u306a\u308b\u7406\u7531\u3068\u3057\u3066\u69d8\u3005\u306a\u898b\u89e3\u304c\u6319\u3052\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u306e\u8ad6\u6587\u306e\u5171\u8457\u8005\u3067\u30ab\u30ca\u30c0\u30fb\u30e2\u30f3\u30c8\u30ea\u30aa\u30fc\u30ebMcGill University\u81e8\u5e8a\u6804\u990a\u5b66\u306eHope A. Weiler\u6559\u6388\u306f\u201c\u30ab\u30ca\u30c0\u201d\u3068\u3044\u3046\u571f\u5730\u3084\u74b0\u5883\u306b\u3064\u3044\u3066\u3082\u8003\u5bdf\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u300c\u4eba\u9593\u306f\u592a\u967d\u5149\u3092\u6d74\u3073\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3082\u30d3\u30bf\u30df\u30f3D\u3092\u5f97\u3089\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u30ab\u30ca\u30c0\u306e\u6c17\u5019\u3067\u306f\u6708\u306e\u307b\u307c\u534a\u5206\u3064\u307e\u308a\u5e74\u9593\u306b\u3059\u308b\u3068\u7d045\uff5e7\u30f6\u6708\u306e\u9593\u3001\u6211\u3005\u306f\u592a\u967d\u306e\u5149\u3092\u307b\u3068\u3093\u3069\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u300d\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u306a\u304a\u3001\u539a\u751f\u52b4\u50cd\u7701\u304c\u767a\u8868\u3057\u3066\u3044\u308b\u65e5\u672c\u3067\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u5fc5\u8981\u6442\u53d6\u91cf\u306f5.5-7.0\u03bcg\/\u65e5\u3068\u5b9a\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5065\u5eb7\u7684\u306a\u98df\u751f\u6d3b\u306b\u6c17\u3092\u4ed8\u3051\u308b\u3053\u3068\u306f\u3082\u3061\u308d\u3093\u3001\u5929\u6c17\u306e\u826f\u3044\u65e5\u306b\u306f\u5916\u3078\u51fa\u3066\u592a\u967d\u306e\u5149\u3092\u305f\u3063\u3077\u308a\u3068\u6d74\u3073\u308b\u3053\u3068\u3082\u598a\u5a20\u3078\u306e\u8fd1\u9053\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u306d\u3002<\/p>\n

\u30d3\u30bf\u30df\u30f3D\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u304c<\/strong>\u80ce\u5150\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/h4>\n

\u6700\u5f8c\u306b\u3001Public Library of Science\u793e\u3088\u308a\u520a\u884c\u3055\u308c\u3066\u3044\u308b\u4e16\u754c\u6700\u5927\u306e\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9\u30b8\u30e3\u30fc\u30ca\u30eb\u3067\u3042\u308bPLOS One<\/em>\u3088\u308a\u3001\u3053\u308c\u3089\u6804\u990a\u7d20\u304c\u80ce\u5150\u3078\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u306e\u6700\u65b0\u306e\u8ad6\u6587\u3092\u3054\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n

\u30ce\u30eb\u30a6\u30a7\u30fc\u30fb\u30c8\u30ed\u30f3\u30cf\u30a4\u30e0Norwegian University of Science and Technology\uff08NTNU\uff09\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306b\u3088\u308b\u3068\u3001\u30ce\u30eb\u30a6\u30a7\u30fc\u56fd\u5185\u306b\u304a\u3044\u3066\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u3092\u6709\u3059\u308b\u598a\u5a66\u306e\u5272\u5408\u304c\u3053\u3053\u6570\u5e74\u306750\uff05\u4ee5\u4e0a\u306b\u4e0a\u6607\u3057\u3001\u598a\u5a663\u4eba\u306b1\u4eba\u306f\u51fa\u7523\u6642\u306b\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u304c\u3042\u308b\u3068\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u305d\u308c\u3089\u306e\u5f71\u97ff\u306b\u3088\u3063\u3066\u65b0\u751f\u5150\u306b\u75be\u75c5\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3082\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30ce\u30eb\u30a6\u30a7\u30fc\u30fbSt. Olavs\u75c5\u9662\u306e\u30b7\u30cb\u30a2\u30b3\u30f3\u30b5\u30eb\u30bf\u30f3\u30c8\u3067NTNU\u516c\u8846\u885b\u751f\u5b66\u306eMiriam K. Gustafsson\u535a\u58eb\u306f\u3001\u30ce\u30eb\u30a6\u30a7\u30fc\u56fd\u5185\u3067\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u306e\u598a\u5a66\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u70b9\u306b\u7740\u76ee\u3057\u3001\u80ce\u5150\u306b\u5bfe\u3057\u3066\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u304c\u3042\u308b\u306e\u304b\u3092\u8abf\u3079\u308b\u305f\u3081\u306e\u8abf\u67fb\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u672c\u7814\u7a76\u3067\u306f\u3001\u30c8\u30ed\u30f3\u30cf\u30a4\u30e0\u304a\u3088\u3073\u30b9\u30bf\u30f4\u30a1\u30f3\u30b2\u30eb\u4e21\u90fd\u5e02\u306e\u598a\u5a66855\u4eba\u3092\u62bd\u51fa\u3057\u3001\u4e00\u5b9a\u671f\u9593\u3054\u3068\u306b\u30d3\u30bf\u30df\u30f3D\u306e\u8840\u4e2d\u6fc3\u5ea6\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u598a\u5a20\u4e2d\u671f\u306e\u6e2c\u5b9a\u3067\u306f\u30c8\u30ed\u30f3\u30cf\u30a4\u30e0\u306e\u5973\u6027\u306e\u7d0447\uff05\u3001\u30b9\u30bf\u30f4\u30a1\u30f3\u30b2\u30eb\u306e\u5973\u6027\u306e\u7d0451\uff05\u304c\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306e\u5024\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u598a\u5a20\u5f8c\u671f\u304a\u3088\u3073\u51fa\u7523\u6642\u306e\u6e2c\u5b9a\u3067\u306f\u5168\u4f53\u306e\u7d0434\uff05\u306e\u5973\u6027\u306b\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u304c\u8a8d\u3081\u3089\u308c\u305f\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u598a\u5a20\u4e2d\u671f\u306b\u91cd\u5ea6\u306e\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u304c\u8a8d\u3081\u3089\u308c\u305f\u598a\u5a66\u3067\u306f\u6b63\u5e38\u306a\u5024\u3092\u793a\u3057\u305f\u598a\u5a66\u3068\u6bd4\u8f03\u3057\u3001\u5b50\u7647\u524d\u75c7\u3084\u598a\u5a20\u7cd6\u5c3f\u75c5\u306e\u7f79\u60a3\u7387\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3001\u65e9\u7523\u3068\u306a\u308b\u78ba\u7387\u3082\u5897\u52a0\u3057\u3066\u3044\u305f\u3068\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u3001\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u306e\u5148\u884c\u7814\u7a76\u306b\u304a\u3044\u3066\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306e\u598a\u5a66\u304b\u3089\u7523\u307e\u308c\u305f\u65b0\u751f\u5150\u3067\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u6d3b\u6027\u304c\u6e1b\u5c11\u3057\u9aa8\u91cf\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u672c\u7814\u7a76\u3067\u3082\u540c\u69d8\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306e\u5150\u306b\u3064\u3044\u3066\u8ffd\u8de1\u8abf\u67fb\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u304f\u308b\u75c5\u306a\u3069\u306e\u9aa8\u683c\u7570\u5e38\u3001\u5c0f\u5150\u5598\u606f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u304b\u3063\u305f\u3053\u3068\u3082\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u30d3\u30bf\u30df\u30f3D\u306f\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u8178\u3067\u5438\u53ce\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u6804\u990a\u7d20\u3067\u3042\u308a\u3001\u598a\u5a20\u4e2d\u3067\u306f\u80ce\u5150\u306e\u9aa8\u91cf\u3092\u5897\u3084\u3057\u3001\u6210\u9577\u30fb\u767a\u80b2\u3092\u7dad\u6301\u3057\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u80ce\u5150\u306e\u767a\u80b2\u306b\u5341\u5206\u306a\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u78ba\u4fdd\u3059\u308b\u305f\u3081\u306b\u306f\u30d3\u30bf\u30df\u30f3D\u306f\u5fc5\u8981\u4e0d\u53ef\u6b20\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

Gustafsson\u535a\u58eb\u306f\u300c\u73fe\u5728\u3001\u598a\u5a20\u306e\u524d\u5f8c\u306b\u63a8\u5968\u3055\u308c\u308b\u6804\u990a\u88dc\u7d66\u5264\u3068\u3057\u3066\u8449\u9178\u3092\u670d\u7528\u3059\u308b\u5973\u6027\u304c\u5897\u3048\u3066\u304a\u308a\u3001\u8449\u9178\u304c\u810a\u9ac4\u6b20\u640d\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u308b\u3068\u3044\u3046\u77e5\u898b\u306f\u4e16\u754c\u4e2d\u3067\u9ad8\u304f\u8a55\u4fa1\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u8fd1\u5e74\u3067\u306f\u69d8\u3005\u306a\u7814\u7a76\u7d50\u679c\u304b\u3089\u30d3\u30bf\u30df\u30f3D\u3084\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u91cd\u8981\u6027\u306b\u95a2\u3059\u308b\u77e5\u898b\u3082\u540c\u3058\u30ec\u30d9\u30eb\u306b\u9054\u3057\u3066\u304d\u3066\u3044\u308b\u3068\u8003\u3048\u308b\u300d\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n

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Gustafsson\u535a\u58eb\u306f\u30d3\u30bf\u30df\u30f3D\u306f\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u3067\u3042\u308b\u305f\u3081\u4f53\u5185\u4f9d\u5b58\u5ea6\u304c\u9ad8\u304f\u3001\u3042\u304f\u307e\u3067\u56fd\u3084\u5c02\u9580\u6a5f\u95a2\u304c\u5b9a\u3081\u308b\u63a8\u5968\u91cf\u3092\u8d85\u3048\u306a\u3044\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u524d\u7f6e\u304d\u3057\u305f\u4e0a\u3067\u3001\u300c\u598a\u5a20\u4e2d\u306e\u5973\u6027\u306b\u3053\u308c\u3089\u306e\u60c5\u5831\u3092\u7a4d\u6975\u7684\u306b\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3067\u3001\u591a\u304f\u306e\u5150\u304c\u6551\u308f\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u4fdd\u5065\u5c40\u3084\u533b\u7642\u6a5f\u95a2\u306b\u304a\u3044\u3066\u306f\u3001\u81e8\u5e8a\u3067\u50cd\u304f\u30b9\u30bf\u30c3\u30d5\u306b\u5468\u77e5\u3055\u308c\u308b\u3053\u3068\u3082\u91cd\u8981\u3060\u300d\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n

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